Dilshad Jahan Graft failure is a significant complication following allogeneic hematopoietic cell transplantation (AHCT). It may be due to rejection caused by recipient T-cells, NK-cells or antibodies. It is increased in HLA-mismatched grafts, unrelated grafts, T-cell replete transplants, sensitized patients … Continue reading →
Abu Jafar Mohammed Saleh Hematopoietic stem cell transplantation (HSCT) is a lifesaving, costly, and multistep procedure. It took more than 50 years from the first published attempt in 1957 to arrive at one million transplants by 2012 and currently more … Continue reading →
Mizanur Rahman, Rummana Rahim, Abu Hasan Paroxysmal nocturnal haemoglobinuria (PNH) is a rare stem cell disorder caused by acquired mutation in the X-linked phosphatidylinositol glycan complementation class A gene. The acquired mutation generates a defect in the expression of glycol-phosphatidyl … Continue reading →
Quazi Smita Haq, Dilsad Jahan, Muhammad Sahidul Islam Sikder, Muhammad Sazzad Zayed Chowdhury, Masba Uddin Chowdhury, Md Maruf Al Hasan, Abu Jafar Mohammed Saleh Background: Diamond-Blackfan anaemia is a rare congenital red blood cell aplasia characterized by failure of erythropoiesis, … Continue reading →
Background: AML is heterogeneous in terms of morphology, immunophenotype, cytogenetics and molecular genetics. Cytogenetic analysis performed at diagnosis is considered to be the most important prognostic factor in AML. The cytogenetic pattern of AML in Bangladeshi population is not clearly … Continue reading →
Background: Acute leukaemia (AL) are a heterogenous group of haematological malignancy characterized by uncontrolled clonal proliferation of haematopoietic progenitor cells. The study was conducted to have a detailed understanding of immunophenotyping profile, the frequency of discrepancy between bone marrow morphology … Continue reading →
APML comprises approximately 5-8% of all Acute Myeloblastic Leukaemia (AML) and is seen mostly in middle aged individuals but can present at any age. It is amongst the most curable malignancies with survival close to 80%. Combination of all-trans-retinoic-acid (ATRA) … Continue reading →
Multiple myeloma (MM) is a neoplastic proliferation of clonal plasma cell producing a monoclonal immunoglobulin. One of the most important discoveries in the past two years was the molecular subclones in almost all patients with MM, which are present at … Continue reading →
Appropriate diagnosis of bleeding disorders needs to follow algorithm of clinical evaluation, screening test for coagulation disorders and planning further tests as per results of screening. Those haemostatic screening tests include platelet count & morphology, bleeding time (BT), prothrombin time … Continue reading →
Background: Acquired Immunodeficiency Syndrome (AIDS) is caused by the HIV virus and characterized by severe immunosuppression that leads to opportunistic infections, haematological aberrations, neoplasms and various deleterious effects on almost all the organs. It is still a major health challenge … Continue reading →
